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Record W7114490623

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control

2024· article· en· W7114490623 on OpenAlexfundno aff

Bibliographic record

VenueNottingham Trent University's Institutional Repository (Nottingham Trent Repository) · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsnot available
FundersNIHR Imperial Biomedical Research CentreEuropean Regional Development FundMedical Research CouncilWalloon excellence in life sciences and biotechnologyAgència de Gestió d'Ajuts Universitaris i de RecercaCanadian Institutes of Health ResearchFondation Brain CanadaEuropean CommissionInstitut MérieuxConseil Régional Hauts-de-FranceInstitució Catalana de Recerca i Estudis AvançatsFonds De La Recherche Scientifique - FNRSInstitut National de la Santé et de la Recherche MédicaleGovernment of CanadaNational Institute for Health and Care ResearchRosetrees TrustOntario GenomicsUniversité de LilleCanada First Research Excellence FundGenome CanadaBritish Heart FoundationCHIST-ERAAustralian GovernmentAgence Nationale de la RechercheWellcome TrustHeart and Stroke Foundation of Canada
KeywordsGlycemicInflammationDiabetes mellitusPathogenesisTrimethylamine
DOInot available

Abstract

fetched live from OpenAlex

Funder: European Metropolis of Lille MEL, Agreement 2019_ESR_11 Isite ULNE (R-002-20-TALENT-DUMAS)

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.016
Threshold uncertainty score0.054

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0160.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.205
Teacher spread0.200 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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