Cannabidiol and multi-modal exercise for cancer survivors suffering from chemotherapy-induced peripheral neuropathy
Bibliographic record
Abstract
Background: Significant advances in cancer treatments have determined increased survival and higher rates of treatment-related sequela. Among these sequela, chemotherapy-induced peripheral neuropathy (CIPN) affects up to 20-40% of patients surviving cancer, who have been receiving taxane and/or platinum-based chemotherapy. Currently, all treatments available for CIPN provide limited benefits. Both cannabidiol (CBD) and multi-modal exercise (MME) have anti-inflammatory and analgesic potential and may provide protection/relief from CIPN. Previously, both interventions have been studied separately, and they have shown good potential to either prevent or treat CIPN in patients undergoing active cancer treatments. However, little is known regarding the effect of a combination of CBD and MME on patients surviving cancer and suffering from CIPN.Purpose: We conducted a four-month interventional open-label study to explore CBD’s effect with and without MME to improve CIPN signs and symptoms, quality of life (QoL) and functional capacity in patients who had completed cancer treatments.Methods: Study patients (n=27) underwent two consecutive two-month interventions, CBD (up to 300 mg/day) followed by CBD combined with MME. The painDETECT questionnaire was used to assess CIPN-related neuropathic pain. CIPN neurotoxic symptoms, perceived physical function and overall QoL were assessed via the Functional Assessment of Cancer Treatment/Gynecological Oncology-Neurotoxicity-13. Participants’ functional status was examined through gait speed and timed up and go for mobility, 9-hole peg test for manual dexterity, hand grip strength and five repetitions of sit-to-stand for dynamic balance and overall strength.Results: After two months of CBD treatment alone, moderate to large positive effect sizes were observed for CIPN neurotoxic symptoms, perceived physical function, and overall muscle strength. Following the combined interventions, large to very large positive effects were noted in CIPN neurotoxic symptoms and perceived physical function. In contrast, moderate to large effects were seen in QoL, gait speed, and manual dexterity.Conclusions: These findings offer proof of concept for the therapeutic potential of CBD, both as a standalone treatment and in combination with MME, in alleviating CIPN symptoms, enhancing QoL and reducing functional impairments among patients who have completed cancer treatments. Further randomized, placebo-controlled trials are warranted to validate these preliminary results. Considerations for future cannabinoid-based clinical studies are also discussed
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".