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Record W7115737945 · doi:10.3389/fanim.2025.1713884

Rumen-protected methionine for dairy and beef cattle: current perspectives on methionine role, supplementation strategies, metabolism, health, and performance

2025· article· en· W7115737945 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueFrontiers in Animal Science · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicRuminant Nutrition and Digestive Physiology
Canadian institutionsUniversity of Guelph
FundersFundação de Amparo à Pesquisa do Estado de Minas GeraisConselho Nacional de Desenvolvimento Científico e TecnológicoNatural Sciences and Engineering Research Council of CanadaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
KeywordsMethionineRumenLimitingDairy cattleAmino acid

Abstract

fetched live from OpenAlex

Protein utilization by ruminants has unique characteristics due to the fractioning into ruminal degraded and undegraded portions. Because of these peculiarities, the amino acid (AA) profile that reaches the intestines for absorption differs from the known dietary protein sources. Among the essential AAs, methionine (Met) is the most limiting nutrient, especially in dairy cattle diets. Moreover, Met contributes to several biological processes, such as protein synthesis, epigenetic regulation, nuclear function, cellular redox potential, phospholipid homeostasis, among others. Hence, given these factors, there are considerable efforts to investigate the efficacy of this AA by employing technologies aimed at shielding it from rumen degradation in both dairy and beef cattle. In light of this, it is valuable to consolidate the findings available in the scientific literature regarding the performance, reproduction, fetal development, and health-related outcomes of rumen-protected methionine (RPM). This approach aims to offer a thorough and unbiased perspective concerning the potential outcomes achievable through the application of this technology. For instance, such insights can serve as a robust foundation for decision-making regarding the implementation of this technology in practical operations. Therefore, this literature review aims to: (1) explore Met metabolism and its importance as a precursor of methyl donors; (2) provide information on the existing methods for protecting Met in the rumen; and (3) compile research findings concerning the potential impacts of Met supplementation on milk production and composition, body weight gain, reproductive outcomes, immune function, and fetal development in both dairy and beef cattle.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.929
Threshold uncertainty score0.372

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.294
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it