Organ-Specific Clinicopathological Features That Are Associated With Post-Relapse Survival of Metastatic Breast Cancer in Japanese Women: A Multicenter Cohort Study
Bibliographic record
Abstract
Background: Metastatic breast cancer (MBC) presents heterogeneous clinical behavior depending on the metastatic site and molecular subtype. However, only a few studies have directly compared prognostic outcomes by the organ of initial distant recurrence. This multi-institutional retrospective study aimed to clarify the clinical and biological characteristics of MBC based on cases with single-organ metastasis at the time of initial MBC diagnosis, using real-world data from Japanese patients. Methods: We retrospectively analyzed 309 Japanese women treated for early-stage breast cancer at six institutions between 2007 and 2021, who developed distant recurrence confined to a single organ (brain, lungs, liver, or bones) as the first site of metastasis. Patients with multi-organ metastases at initial recurrence were excluded. Results: The median distant metastasis-free survival and post-relapse survival (PRS) were 29.4 and 39.7 months, respectively. PRS was longest in patients with bone recurrence, followed by those with lung and liver recurrence, and shortest in those with brain recurrence (P < 0.001). Bone and lung metastases were more frequently associated with hormone receptor-positive tumors, whereas liver and brain metastases were enriched for human epidermal growth factor receptor 2 (HER2)-negative and triple-negative tumors. The multivariable Cox model identified older age, triple-negative subtype, and symptomatic recurrence as independent poor prognostic factors, while liver and brain metastases were also independently associated with shorter PRS. Site-specific analyses revealed that triple-negative subtype and symptomatic presentation were consistent markers of poor prognosis across most metastatic sites. Conclusions: Based on a single-organ metastasis cohort, this study identified distinctive clinicopathological features and survival outcomes according to the site of initial distant recurrence. Brain metastases were associated with the poorest outcomes, highlighting the need for improved risk stratification and treatment strategies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".