Does the MC4R rs17782313 gene polymorphism affect the rate of exercise-induced fat oxidation?
Bibliographic record
Abstract
This study investigated the effect of the MC4R rs17782313 ( T > C) polymorphism on substrate oxidation and metabolic responses during exercise in healthy sedentary men. Forty-eight participants (aged 20–30 years) underwent genotyping and completed a graded exercise test with respiratory gas analysis to assess oxygen consumption (VO 2 ), respiratory quotient (RQ), and fat and carbohydrate oxidation rates. Participants were grouped as C-allele carriers (risk allele) and TT homozygotes. Group comparisons were conducted for VO 2 , RQ, substrate oxidation rates, and body mass index (BMI). Statistical analysis revealed no significant differences between genotypes in RQ, fat oxidation percentage, or carbohydrate oxidation percentage during moderate-intensity exercise ( p > 0.05). However, significant differences were observed in BMI, with C-allele carriers exhibiting higher BMI values compared to TT homozygotes ( p < 0.05). These results indicate that while the MC4R rs17782313 variant is associated with increased adiposity, it does not appear to affect acute substrate utilization during exercise. Thus, its contribution to obesity risk may be primarily mediated by behavioral and neuroendocrine mechanisms influencing energy intake rather than impairments in metabolic flexibility.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".