Acute pancreatitis as a complication of epstein-barr virus infection: A case report and narrative review
Why this work is in the frame
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Bibliographic record
Abstract
Epstein–Barr virus (EBV) infection is common, but EBV-associated acute pancreatitis is rare and heterogeneous. We describe an adult case and synthesize published cases to inform diagnosis and management. Case presentation : A 40-year-old man presented with sore throat and mild abdominal pain; examination showed a right peritonsillar abscess with uvular deviation. Laboratory testing revealed lipase 3704 U/L and elevated inflammatory markers; abdominal CT confirmed non-complicated acute pancreatitis. He received incision and drainage of the abscess plus conservative pancreatitis care. Symptoms resolved rapidly, lipase decreased to 352 U/L by day 2, and he was subsequently discharged. EBV serology later confirmed acute infection, and patient was asymptomatic at 2-month follow-up. We searched PubMed to August 24, 2025, using (“Epstein-Barr virus” OR “EBV”) AND “pancreatitis,” including human case reports or series of EBV-associated acute pancreatitis. There were no language restrictions. Of 60 records, 13 cases met criteria. Eight involved adults and most patients were female. Abdominal pain was common, but classic mononucleosis symptoms were infrequently reported. CT was the predominant diagnostic modality. Management was conservative in nearly all reports and antivirals were rarely used. Outcomes were generally favorable, with one fatal case. EBV should be considered in unexplained acute pancreatitis, particularly when common etiologies are excluded or concurrent EBV features are present. Prognosis is typically good with supportive care, but coexisting risk factors may predispose patients to a more severe or complicated course. Transparent reporting of cofactors will clarify whether EBV acts as an opportunistic trigger or independent cause. • EBV-associated acute pancreatitis is a rare but recognized complication in both pediatric and adult patients. • The clinical presentation is heterogeneous and may often lack typical features of infectious mononucleosis • Conservative management is usually sufficient, and prognosis is favorable in most cases. • Coexisting risk factors (alcohol use, hypertriglyceridemia, medications) may lower the threshold for EBV-related pancreatic inflammation. • Transparent reporting of additional risk factors is needed to clarify whether EBV acts as an opportunistic trigger or an independent cause of pancreatitis.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it