Prospective Longitudinal Cohort of Argentinean Patients with Progressive Supranuclear Palsy: A Platform for Epidemiological and Translational Research
Bibliographic record
Abstract
BACKGROUND: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are two neurodegenerative disorders that manifest disabling postural instability, parkinsonism, cognitive impairment and falls with brain neurofibrillary tangle lesions containing 4-repeat tau protein. The prevalence is 6/100,000 inhabitants but estimated only from descriptions made in North America, Europe or Japan. To describe a multicenter collaborative initiative for studying the epidemiology and tau biology of Argentinean patients with PSP and CBS, Consorcio Argentino de Investigación Traslacional en Tauopatias Primarias (CAITauP). METHOD: A prospective observational cohort of people with PSP (PwPSP) and CBS will be longitudinally studied. Deep clinical phenotyping, neurocognitive testing every 12 months, and biosamples collection at baseline are planned. Disease severity will be assessed every 6 months and history of environmental exposures will be assessed at baseline. RESULT: There were 50 patients enrolled with PSP (36), CBS (10), and undifferentiated parkinsonism with cognitive impairment (4). Female gender was 51%, mean age 74 years, with estimated disease duration of 5.5 years. Ethnicity was mostly Hispanic/Latino (78%), european descendant (28.5%), and assian (1.5%). Variant phenotypes of PSP were: 36% Richardson syndrome, 19%PSP-Progressive gait freezing, 18% PSP-corticobasal, 14% PSP-parkinsonsm, 9% PSP-Speech/languaje variant, 3% PSP-pure postural inestability, and 1,5% pure PSP-oculomotor. Disease severity measured by the PSP-rating scale (PSPRS) was 54. Preliminary findings of the initially enrolled patients showed that more than 60% of enrolled patients have completed first visit and biosamples collection, and two patients underwent brain donation. Environmental exposures of a subsample are reported and compared to those of patients with Parkinson's disease. CONCLUSION: The CAITauP includes a comprehensive cohort of PwPSP in Argentina that has achieved progress in patient recruitment, deep clinical phenotyping and biobanking. Early findings highlight the feasibility of translational research in tauopathies in developing countries of South America. The consortium aims to address underrepresented groups of South American populations in ongoing research aimed to improve diagnosis, treatment, and to create trial-ready cohorts that enhance translational research in PSP.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".