Automatic construction of interconnected cable models of cardiac propagation on a surface
Why this work is in the frame
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Bibliographic record
Abstract
BACKGROUND AND OBJECTIVE: Cardiac fibers may be represented by a network of interconnected cables for simulating electrical propagation. The lack of automatic cable mesh generation tool has hampered this modeling approach. We aim to provide and evaluate an algorithmic solution to this problem. METHODS: We developed an open-source C++/Python package for the construction of a monolayer interconnected cable model from a triangulated surface with fiber orientation, targeting a given longitudinal and transverse space step. The workflow of the algorithm starts with the generation of evenly spaced streamlines aligned with fiber orientation. Another set of streamlines, orthogonal to the fibers, is used to specify lateral connections. The intersection between the two sets of streamlines gives the vertices of the cable mesh, determines its connectivity, and defines a polygonal tessellation of the surface that can be triangulated. Finite differences can then be applied to solve a reaction-diffusion equation on the cable mesh. RESULTS: The approach was validated in increasingly complex configurations and up to near-cellular resolutions (20 to 200μm). Fiber orientation noise, singularities and abrupt changes in orientation reduced the local coupling by altering the microstructure of the tissue. The pipeline for mesh generation was tested using a publicly available cohort of 98 patient-specific geometries. The stability limit of the numerical scheme was assessed by spectral analysis of the diffusion matrix and was compared to triangular meshes and cartesian grids. CONCLUSION: This physiologically based mesh generation tool may be used as a building block for the construction of multilayer three-dimensional models of the atria for the simulation of discrete propagation.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it