Adipocyte‐specific ablation of plakoglobin in mice does not affect adiposity but results in sexual‐dimorphic effects on weight gain
Bibliographic record
Abstract
The main transcriptional coactivator of the WNT pathway, β-catenin, is a well-established regulator of adipogenesis and fat expansion, but our knowledge of how other members of the catenin family participate in adipogenesis remains incomplete. Previous studies have elucidated a role for the β-catenin homolog, plakoglobin, in the regulation of adipogenesis in vitro, as its depletion impaired lipid accumulation. Moreover, plakoglobin overexpression in murine cardiomyocytes has been reported to enhance adipogenesis within the heart, further implicating its role as a key regulator of differentiation. In the present study, we investigated the adipocyte-specific contributions of plakoglobin to adipogenesis and metabolism. Although deletion of plakoglobin in mature adipocytes had sex-specific effects on body weight gain, whereby only chow-fed knockout females weighed more than controls, no differences in adiposity or adipocyte size were observed. Moreover, no differences in glucose tolerance or insulin sensitivity were noted. Challenging mice with a high-fat diet revealed diet-induced metabolic disturbances only in male mice, but had no impact on adiposity or body weight. Together, our data demonstrate that plakoglobin in mature adipocytes is not required for adipogenesis or the expansion of adipose tissue mass.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".