Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance
Bibliographic record
Abstract
The decline in ovarian endocrine function represents a pivotal event in female aging, initiating systemic biological deterioration well before the end of reproductive capacity. We propose that Hormone Replacement Therapy (HRT) may constitute an early stage geroprotective intervention with mechanistic relevance across the 12 hallmarks of aging. Despite extensive clinical use, HRT remains underutilized as a geroprotector. Although there is promising data, prospective, biomarker-driven interventional studies are required to test this paradigm. This narrative review outlines the role of HRT as a geroprotective therapy, preferably offered and started within 10 years of menopause onset, in clinically eligible women in perimenopause. We emphasize the need for specific clinical guidelines that reflect and manage the endocrine, inflammatory, and metabolic profiles unique to perimenopause. The development of age- and phase-specific biomarkers will be critical to optimize HRT use and ensure precision delivery of longevity-focused care for women.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.013 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.006 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".