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Record W7117406614 · doi:10.1016/j.kint.2025.11.021

Utilizing risk prediction models for older patients with chronic kidney disease

2025· article· en· W7117406614 on OpenAlexafffund
Amanda Siriwardana, Navdeep Tangri, BRENDON NEUEN, M Jardine, Celine Foote, M. W. Gallagher

Bibliographic record

VenueKidney International · 2025
Typearticle
Languageen
FieldMedicine
TopicChronic Kidney Disease and Diabetes
Canadian institutionsSeven Oaks General Hospital
FundersJanssen PharmaceuticalsCanadian Institutes of Health ResearchNational Institutes of HealthOtsuka PharmaceuticalAkebia TherapeuticsNovo NordiskResearch ManitobaCSL BehringAstraZenecaEli Lilly and CompanyKidney Foundation of CanadaAmgen
KeywordsKidney diseaseNephrologyRisk assessmentPredictive modellingRisk modelChronic renal failureDiseaseKidney

Abstract

fetched live from OpenAlex

Older patients represent the most rapidly growing age group presenting with kidney failure. Despite this high incidence, the rate of progression to kidney failure tends to be slower in older individuals, and the competing risk of death before the development of kidney failure is a more significant consideration in older patients compared with younger counterparts. Incorporating these concepts of risk is challenging in shared decision-making discussions between clinicians, older patients, and their families. Risk prediction models are rapidly increasing in nephrology and have the potential to provide personalized absolute risk prediction for patients with advanced chronic kidney disease; however, there are several considerations of these models relevant to older patient populations. This review discusses metrics for assessing risk prediction models, examines key models for predicting kidney failure and mortality risk in older patients with advanced chronic kidney disease, and provides guidance for how best to interpret and use these models to support personalized decision-making processes with older patients.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.012
metaresearch head score (Gemma)0.058
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.013
Threshold uncertainty score0.065

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0120.058
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0030.002
Science and technology studies0.0010.000
Scholarly communication0.0040.002
Open science0.0010.002
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.257
Teacher spread0.248 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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