Epidemiology and Long-Term Treatment Outcome of Central Neurocytoma: A Retrospective National Study from Saudi Arabia
Bibliographic record
Abstract
OBJECTIVE: To describe the clinical features, management, and long-term outcomes of central neurocytoma (CNC). METHODS: A retrospective cohort included all histopathologically confirmed CNC cases treated at 11 tertiary centers in Saudi Arabia from 1996 to 2021. Overall survival (OS) and progression-free survival (PFS) were estimated with Kaplan-Meier and compared with the log-rank test. Postoperative radiation was modeled as a time-dependent exposure to address immortal time bias. Functional outcomes were assessed with the modified Rankin Scale. RESULTS: were associated with poorer OS (P = 0.018) and functional outcomes (P = 0.002). At last follow-up, 81.7% of patients maintained functional independence (modified Rankin Scale ≤ 2). CONCLUSIONS: CNC offers favorable long-term survival and functional outcomes. Maximal safe resection remains the mainstay of treatment, while the benefit of postoperative radiation appears limited. Tumor size remains a key determinant of outcome.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".