What is known about muscle weakness, balance impairments and indoor mobility limitations in oculopharyngeal muscular dystrophy? A scoping review
Bibliographic record
Abstract
Objective: The objective of this scoping review was to map the body of existing literature regarding muscle strength, balance and mobility limitations in oculopharyngeal muscular dystrophy (OPMD). Methods: The Joanna Briggs Institute's methodology was followed. All original research including participants with OPMD 18 years or older and describing muscle strength, balance and/or mobility limitations using clinical outcome assessments retrieved from the PubMed, MEDLINE, PEDro, Cochrane Database of Systematic Reviews, and CINHAL Plus databases (searched before January 30 th , 2023) were included. Results: Titles and abstracts from 416 studies were screened, and 54 articles were fully reviewed. Proximal upper and lower limb muscle strength were assessed in majority (92.6% of studies). Lack of common methodology made conclusions on their prevalence and severity difficult. Regarding balance, no performance outcome measures was retrieved. 29.6 to 63.0% of studies addressed mobility limitations; only two prospective longitudinal studies were retrieved, and two studies used reference values to assess impairments/limitations severity. Conclusion: This scoping review highlights the current knowledge on muscle strength, balance and mobility limitations in OPMD. A lack of balance and complete mobility assessments, and OPMD-specific questionnaire for motor impairments or mobility limitations are noted. Future studies should focus on using standardized clinical outcome assessments to better document these impairments/limitations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".