The Impact of Donating Human Milk on the Health of the Donor and Their Infant: Evidence from Two Systematic Reviews
Bibliographic record
Abstract
Using human milk has been associated with decreased morbidity and mortality in preterm/low birth weight infants. Donor human milk is recommended when maternal milk is unavailable. The benefits of donor human milk for the recipient are well documented, but the impact of donation on donors and their infants is not clear. We aimed to evaluate the effects of donation human milk on donors and their infants. Literature searches were conducted (April 2024) to identify studies (observational, quasi-experimental, and randomized control trials) assessing the impact of human milk donation on donor health, nutrition, well-being, and lactation and on their infants' health, growth, and development. Bias was assessed using the Risk of Bias in Non-randomized Studies - of Interventions scale. Meta-analysis was conducted when possible. Certainty of evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. Nine studies examined donor outcomes, and 6 studies examined donor infant outcomes. No differences were found between donors and nondonors regarding the prevalence of overweight [risk ratio (RR): 1.27; 95% confidence interval (CI): 0.81, 2.01], postpartum depression (RR: 0.60; 95% CI: 0.21, 1.72), postpartum anxiety (RR: 0.84; 95% CI: 0.59, 1.18), need to pump for their infant (RR: 1.09; 95% CI: 0.63, 1.89), mastitis (RR: 1.48; 95% CI: 0.71, 3.05), chapped/cracked nipples (RR: 0.61; 95% CI: 0.34, 1.12), and breast engorgement (RR: 1.88; 95% CI: 0.94, 3.77). Similarly, no differences were found between donor and nondonor infants regarding feeding intolerance (vomiting) (RR: 1.26; 95% CI: 0.53, 3.01), slow weight gain (RR: 0.36; 95% CI: 0.13, 1.02), oral thrush (RR: 0.55; 95% CI: 0.12, 2.37), or need for phototherapy (RR: 2.21; 95% CI: 0.93, 5.23). The certainty of evidence was very low for all outcomes. Limited, very low certainty evidence does not support any short-term harms or benefits of human milk donation for donors or their infants. The protocols for both studies were registered with the International Prospective Register of Systematic Reviews (PROSPERO) on March 26, 2024. Study IDs: CRD42024529222 and CRD42024528803.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".