Cognitive and Neuropsychiatric Sequelae in Postpartum Women with Preeclampsia: A Prospective Cohort Study
Bibliographic record
Abstract
Objective: This study aimed to prospectively evaluate cognitive function and neuropsychiatric outcomes in postpartum women with a history of preeclampsia compared to normotensive controls. It further sought to identify key predictors of cognitive impairment and mood disturbances within this high-risk group. Materials and Methods: Between January and December 2024, a forward-looking cohort investigation was implemented at a tertiary healthcare institution. A total of 280 postpartum participants were included, comprising 160 women diagnosed with preeclampsia and 120 normotensive counterparts, with both groups balanced in terms of age and parity. Cognitive performance was measured using the Montreal Cognitive Assessment (MoCA), while emotional health was monitored through the Hospital Anxiety and Depression Scale (HADS) and the Edinburgh Postnatal Depression Scale (EPDS) during follow-up visits conducted at 6 and 12 months after childbirth. Results: At 12 months postpartum, women in the preeclampsia group exhibited significantly lower mean MoCA scores (23.6 vs. 26.1, p<0.001) and a higher prevalence of clinically significant anxiety (38.1% vs. 15.8%) and depression (29.4% vs. 10.8%) than controls. Logistic regression identified severe preeclampsia, low educational status, and elevated EPDS scores as independent predictors of cognitive impairment. Conclusion: Women with a history of preeclampsia are at increased risk for cognitive and psychiatric sequelae in the postpartum period. These findings underscore the importance of structured neuropsychiatric screening and early intervention in postpartum care for this high-risk population.
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Observational | low |
| gpt | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Observational | low |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".