Dynamic assessment of myocardial perfusion and contractility in patients with refractory angina under combined intermittent hypo-hyperoxic therapy. (Clinical Trial No. REFRANGINA-TRIAL protocol)
Bibliographic record
Abstract
The clinical trial No. REFRANGINA-TRIAL protocol is aimed at dynamic assessment of myocardial perfusion and contractility in patients with refractory angina under combined intermittent hypo-hyperoxic therapy. Refractory angina characterized by persistent symptoms and impaired functional status despite optimal medical treatment, as well as ineffective invasive revascularization affects 5—10% of patients with coronary artery disease. The study will enroll 60 patients with coronary artery disease and refractory angina class II—III confirmed by stress tests. Patients will be randomized into three groups: group 1 — combined therapy (10 sessions of intermittent hypo-hyperoxic therapy over 2 weeks and 5-week medical therapy beginning 3 weeks prior to hypo-hyperoxic sessions); group 2 — a course of hypo-hyperoxic therapy with placebo (10 sessions over 2 weeks); group 3 — standard treatment according to current protocol. Treatment efficacy will be evaluated using contrast-enhanced perfusion MRI, echocardiography (with measurement of ejection fraction and global longitudinal strain of the left ventricle), stress tests (treadmill test and 6-minute walk test), as well as assessment of endothelial function by NICaS method and quality of life (SF-36 questionnaire). Treatment safety will be monitored through regular checks of vital signs, ECGs, laboratory tests, and physical examinations, along with recording of adverse events. The study is conducted in strict accordance with the Declaration of Helsinki, legislation of the Russian Federation, and Good Clinical Practice standards (ICH-GCP). It is anticipated that final results will confirm safety and efficacy of this new non-invasive approach for treating refractory angina. This will optimize therapeutic strategies and update clinical guidelines in the Russian Federation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.013 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".