Cognitive function and dementia risk in midlife adults with cardiovascular disease
Bibliographic record
Abstract
Abstract Background Cardiovascular disease (CVD) contributes to dementia risk, as cerebrovascular dysfunction and systemic inflammation play key roles in cognitive decline. Neurodegenerative changes, including tau accumulation, begin decades before clinical symptoms emerge, making midlife a critical period for identifying at-risk individuals. Understanding the interplay between vascular health, inflammation, and cognition in midlife adults with CVD is essential for early intervention and prevention strategies. Purpose This study examines the associations between CVD burden, inflammation, and cognitive function in middle-aged adults with CVD to identify early markers of dementia risk. Methods A cross-sectional analysis was conducted as part of an ongoing study enrolling middle-aged adults with CVD. CVD burden was assessed using a composite score of CV risk factors. Cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA), Trail Making Test A & B (processing speed & executive function), Judgment of Line Orientation (JOLO; visuospatial ability), Rey-Osterrieth Complex Figure Test (Rey-O; visuospatial), Multilingual Naming Test (MINT; language), and Mental Rotation Test (MRT; spatial reasoning). Plasma biomarkers of neurodegeneration (total tau [t-tau] and p-tau217) and inflammation (C-reactive protein [CRP], triggering receptor expressed on myeloid cells [TREM]-1, interleukin [IL]-1β) were measured via ELISA. Results Participants (N=40) were 66±8 years of age, 55% female, and 38% Black and African American. CVD burden was positively associated with t-tau (r=.595, p<.001) and p-tau217 (r=.623, p<.001). Elevated t-tau and p-tau217 levels correlated with longer times on Trails B (t-tau: r=.425, p=.006; p-tau217: r=.431, p=.006). Diastolic blood pressure was associated with lower global cognition (MoCA: r=-.344, p=.030) and higher t-tau (r=.459, p=.003). Higher IL-1β levels were associated with poorer visuospatial performance (JOLO: r=-.449, p=.004; Rey-O: r=-.346, p=.029), reduced language ability (MINT: r=-.459, p=.003), and slower processing speed (Trails A: r=.349, p=.027). CRP was negatively associated with spatial reasoning (MRT: r=-.386, p=.014). Conclusions These preliminary findings suggest CVD burden and inflammation may contribute to early neurodegenerative processes and cognitive dysfunction in midlife adults, a critical window for dementia prevention. Elevated markers of neurofibrillary tangles (p-tau217) and global neurodegeneration (t-tau) indicate CVD may accelerate brain pathology decades before clinical symptoms emerge. Cognitive decline in this population appears most pronounced in executive function, processing speed, and visuospatial abilities, domains affected in both AD and vascular cognitive impairment. Given the increasing recognition of heart-brain interactions, cognitive screening should be integrated into CVD management, particularly for individuals with high inflammatory burden or vascular dysfunction.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".