Assessment of thiol/disulphide homeostasis in patients with knee osteoarthritis
Bibliographic record
Abstract
© 2021, National Institute of Science Communication and Information Resources. All rights reserved.Our aim was to explore the thiol/disulphide homeostasis and the link with functional status in patients who have knee OA. Sixty knee OA patients and 50 healthy individuals were enrolled in this study. We measured serum levels of native thiol, total thiol and disulphide. In order to measure the alterations in functional status such tests as the Western Ontario, MacMaster Osteoarthitis index (WOMAC), walking test and Visual Analogue Scale (VAS) were utilized. The total thiol levels were higher in the control group than the knee OA patients (P< 0.05). Disulphide and disulphide/total thiol levels were significantly lower when control group were compared to knee OA patients (P< 0.05).Activity pain was negatively associated with native thiol levels (P< 0.05), walking test scores were negatively correlated with the native thiol levels (P< 0.05) and positively correlated with disulphide levels (P< 0.05) in knee OA patients. In knee OA patients, no correlation was observed between thiol/disulphide parameters and WOMAC scores. Conclusion, thiol/disulphide homeostasis is impaired in patients with knee osteoarthritis. Disulphide level increased and thiol level decreased due to oxidative stress. Thiol/ disulphide homeostasis had not noticeable impact on the on functional status. Thiol/disulphide homeostasis may help to explain the pathogenesis of osteoarthritis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".