Bibliographic record
Abstract
Bronchiolitis obliterans remains the most common cause of morbidity and mortality following lung transplantation. Using a murine heterotopic tracheal transplant model, we explored the molecular mechanisms, namely apoptosis, the renin-angiotensin system and matrix metalloproteinases involved in the pathogenesis of bronchiolitis obliterans. We examined therapeutic interventions, such as ACE inhibition, Angiotensin II receptor blockade, caspase inhibition and matrix metalloproteinase inhibition, in the prevention and treatment of bronchiolitis obliterans. The following conclusions were made: (1) Apoptosis of airway epithelial cells does occur in the setting of allograft airway transplantation. However the inhibition of apoptosis, through broad-spectrum caspase inhibition or Fas pathway blockade, only partially prevents airway obliteration. (2) ACE inhibition, but no angiotensin II receptor blockade, significantly reduces transplant-induced airway obliteration. (3) Matrix metalloproteinases (MMP) are involved in the pathogenesis of allograft-induced airway obliterative lesions. Treatment with an MMP inhibitor significantly reduces airway obliteration and promotes airway re-epithelialization in allograft transplants.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".