Bibliographic record
Abstract
Blood pressure regulation has conventionally been attributed to the cardiovascular, neuroendocrine, and renal systems, with water and sodium handling by the kidneys being essential for systemic fluid balance and long-term blood pressure homeostasis. Recently, the immune system has emerged as an important contributor to blood pressure control and hypertension pathophysiology. This Dissertation examines B cells and immunoglobulin A (IgA) in murine blood pressure regulation through alterations in renal water and sodium handling: causal roles of B cells in blood pressure control were studied using an inducible model of B cell depletion, and contributions of IgA to blood pressure and hypertension were examined in an IgA-deficient model. Chronic B cell ablation had a blood pressure-lowering effect in male mice, while IgA-deficient mice exhibited reduced blood pressures and blunted responses to experimental hypertension. This Dissertation highlights contributions of B cells and IgA to blood pressure regulation through mechanisms of renal fluid balance.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".