Bibliographic record
Abstract
The mechanisms governing the lineage-specific transcriptional regulation of CD45 are unknown. CD45 utilizes three mutually exclusive promoters: P1a, P1b, and P2. It was found that transcription of CD45 primarily initiated from P1b in the myeloid and lymphoid lineages in all hematopoietic cell lines and primary cells tested, except for the thymoma cell line EL4. Real-time RT-PCR assays with a series of reporter constructs that covered various upstream sequences showed that an element between -438 and -420 upstream of P1b was identified to repress transcription from P1a in M12 (B lymphoma) and EL4 and activate transcription from P1b in RAW264.7 (Macrophage). EMSA identified that Oct-1 binds this region in RAW264.7, M12, and EL4. In addition, Oct-2 binds this region in EL4. Therefore, the Octamer factors are involved in the transcriptional regulation of CD45 in both the myeloid and lymphoid lineages.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".