Bibliographic record
Abstract
Insulin-induced GLUT4 translocation in muscle cells involves the activation of Akt and Rac1-mediated actin remodelling, both downstream of PI3K. Our study was aimed at establishing the nature of the relationship between these two signalling arms. The first aim was to test the existence of crosstalk between Akt and Rac1, in an acute fashion. Our results confirm that Akt does not regulate Rac1 activation or actin remodelling. Interestingly, we observed an Akt-dependent activation of Cdc42 in response to insulin. The second aim was to analyze the function of a cytoskeletal protein, FLNc, as a "molecular bridge" between the Akt and Rac1 signalling cascades. The results of this thesis establish that FLNc is an in vivo substrate of Akt. However, we failed to see any functional significance of FLNc in insulin action. Our present study offers further support to the theory of bifurcation of PI3K signals into Akt and Rac1-dependent actin remodelling.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".