Bibliographic record
Abstract
Zinc plays a role in insulin processing, storage, and secretion. Zinc transport processes may be linked to defects in insulin secretion associated with type 2 diabetes (T2D). Indeed, ZnT8, a zinc influx transporter highly expressed in pancreatic β-cells, is associated with T2D risk. Presently, the role ZnT8 plays in diabetes progression and whether altered ZnT8 activity affects T2D risk/treatment is controversial. The effects of ZnT8 knockdown in mouse are modestly to severely deleterious, whereas in humans, ZnT8 loss-of-function haploinsufficiency appears to reduce diabetes risk. A β-cell specific ZnT8 knockout and haploinsufficiency model were developed and examined under normal and metabolically stressed conditions. Mice with reduced ZnT8 did not have significantly impaired glucose homeostasis or β-cell function compared to controls under normal and conditions of acute insulin resistance. Overall, pancreatic β-cell ZnT8 deletion or knockdown did not impair β-cell function, nor was it protective of hyperglycaemia associated with insulin resistance.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".