Vascular Leakage in Acute Respiratory Distress Syndrome: The Role of Endothelial Cell Death and Endothelial Regeneration
Bibliographic record
Abstract
Acute Respiratory Distress Syndrome (ARDS) is a severe pulmonary illness characterized by the disruption of the alveolar-capillary barrier that leads to vascular leakage and pulmonary edema. One important mechanism for vascular leakage is endothelial cell death, while endothelial regeneration helps repair vascular integrity. Multiple types of cell death have been described but their relative contribution to endothelial leakage in ARDS is unknown. The contribution of endothelial regeneration pathways to recovery from ARDS is also poorly characterized. We developed both lethal and sublethal influenza A induced-ARDS models in vivo to compare the frequency and mechanisms of endothelial cell death and regeneration. We observed a significant loss of lung microvascular endothelial cells in the lethal but not the sublethal model and found that microvascular endothelial apoptosis, instead of pyroptosis or necroptosis, may contribute to lethality. Additionally, we found that FoxM1-mediated endothelial regeneration pathways might be impaired in the lethal model. Accordingly, future ARDS therapies should aim to inhibit endothelial apoptosis or augment endothelial regeneration through the FoxM1 pathway.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".