A Multimodal Neuroimaging Study of Alcohol Use Disorder: Functional Connectivity, Endocannabinoid Metabolism and Clinical Outcomes during Abstinence
Bibliographic record
Abstract
Alcohol use disorder (AUD) is marked by dysregulation of functional connectivity (FC) which may be pertinent to symptoms during abstinence. Fatty acid amide hydrolase (FAAH), a metabolizing enzyme of anandamide, modulates frontoamygdala FC. We investigated the abnormalities of FC in AUD and whether impairments were associated with higher FAAH levels and poorer clinical outcomes. AUD and control participants completed a resting-state MRI and PET scan with the FAAH tracer, [11C]CURB. Frontoamygdala FC was significantly lower in AUD than controls, with a greater effect in severe AUD participants. In AUD, no relationship was found between FAAH and frontoamygdala FC. Frontoamygdala FC showed a significant negative correlation with mood and withdrawal symptoms. Lower frontoamygdala FC was seen in AUD, which was related to clinical outcomes, but not FAAH levels. The current study suggests that lowered FC may be clinically relevant, and the role of FAAH in regulating FC may differ in AUD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".