The Role of Endothelial-Specific Intraflagellar Transport Protein 88 in Doxorubicin-Induced Cardiotoxicity
Bibliographic record
Abstract
Doxorubicin (DOX) has been associated with cardiotoxicity resulting in heart failure. Previous studies focused on cardiomyocytes as therapeutic targets. However, there has been a shift of focus toward endothelial cells (ECs) due to its importance in cardioprotective processes. Recently, a role for EC primary cilia as central structures that govern EC function through downstream signaling upon blood flow stimulation was identified. Intraflagellar transport protein 88 (IFT88) is critical for ciliary formation. In our study, mice with EC-specific loss of IFT88 expression (EC-IFT88-/-) were utilized to investigate the role of EC primary cilia in DOX-induced cardiotoxicity. We observed greater DOX-induced mortality and reduced cardiac function in EC-IFT88-/- mice compared to wild-type (WT) littermates. Furthermore, weakened statistical power may have contributed to unobservable significant differences in CM vacuolization and cardiac fibrosis of DOX-treated EC-IFT88-/- and WT littermates. Thus, EC primary cilia may be involved with processes that are protective of DOX-induced cardiotoxicity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".