Characterization of SAD-1 kinase activity and genetic pathway in the nervous system of Caenorhabditis elegans
Bibliographic record
Abstract
Neurons are highly polarized cells that communicate through synapses. Identified in Caenorhabditis elegans (C. elegans), the serine/threonine kinase SAD-1 was the first molecule known to regulate both neuronal polarity and synaptic structure in vivo. For my Master's thesis, I studied the kinase activity of SAD-1 and its candidate regulators in C. elegans nervous system. Selective temporal inactivation of the SAD-1 kinase with pharmacogenetics demonstrates that its kinase activity is essential for the proper formation of neuronal polarity and synaptic marker morphology but largely dispensable for their maintenance. Genetic analyses indicate that candidate regulators of the SAD-1 kinase, PAR-1, PAR-4, and STRD-1, all regulate neuronal polarity and synaptic marker morphology. However, while strd-1 appears to function exclusively in the sad-1 pathway, par-1 and par-4 can function independently of sad-1. These data suggest that par-1, par-4, sad-1, and strd-1 regulate neuronal polarity and synaptic marker morphology in multiple genetic pathways.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".