Effect of vitamin D treatment in ANCA-associated vasculitis: results from an exploratory perspective, pragmatic, non-randomised study
Bibliographic record
Abstract
OBJECTIVES: Vitamin D deficiency has been linked with several autoimmune diseases. Data are limited in anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV), and it is unknown whether vitamin D could have a therapeutic role in AAV. METHODS: The prospective, pragmatic, non-randomised exploratory PRAVDA study with ITT and pre-protocol analyses aimed to enrol >100 patients with AAV at the Vasculitis Clinic (Toronto, Canada) from January to July 2021. 25-hydroxyvitamin D [25(OH)D] was measured at baseline by ELISA. Patients with low 25(OH)D (<75 nmol/L at baseline) were asked to increase vitamin D supplementation by 1000 IU/day (to a maximum 2000 IU/day). 25(OH)D was measured again at month 12. The primary endpoint was 12-month disease relapse. Secondary analyses included correlations between vitamin D status and disease-specific clinical features. RESULTS: The study included 101 patients, 41 (40.6%) of whom had low baseline vitamin D levels and were asked to increase vitamin D3 intake. Of these patients, 32 had vitamin D level reassessed at month 12; 62.5% (20/32) had achieved normal levels. Relapse rates at month 12 were similar between patients with low (n=3/41; 7.3%) and normal (n=6/60; 10%; p=0.64) baseline vitamin D levels. However, no relapses were observed in patients who corrected baseline vitamin D deficiency. CONCLUSIONS: These findings can help designing larger studies on vitamin D supplementation in AAV patients, focusing mostly on those vitamin D deficient at baseline.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".