Bibliographic record
Abstract
Background. Systemic lupus erythematosus (SLE) is associated with considerably elevated rates of coronary heart disease (CHD). Understanding the reasons for this is crucial for developing effective CHD prevention and treatment in SLE patients. Objective. To gain insights into biological mechanisms underlying the accelerated atherosclerosis in SLE, this thesis examines (i) the longitudinal evolution of traditional coronary risk factors and global coronary risk, and (ii) the independent effects of corticosteroid use and lupus disease activity on this evolution. Methods. First, a systematic comparison between alternative approaches to global coronary risk assessment was performed based on data from the Framingham Heart Study to determine the optimal method of representing the aggregate impact of individual risk factors. Next, data on up to 30 years of follow up of 310 lupus patients of the Montreal General Hospital Lupus Clinic and 26 years of follow-up of 4,367 control subjects from the Framingham Offspring Study were used to investigate, in separate analyses, the independent associations of lupus disease duration with the global coronary risk and each conventional risk factor. Finally, the lupus cohort was used to study the associations of recent corticosteroid use and recent lupus disease activity with a series of CHD risk factors and global CHD risk. Main analyses relied on multivariable linear mixed models for longitudinal data. Findings. Updated risk factor values improved the predictive ability of the multivariable coronary risk score compared with prediction based on baseline values. Longer lupus disease duration was associated with increased blood glucose levels, systolic blood pressure and total cholesterol. Recent corticosteroid use and recent lupus disease activity were both positively associated with increases in the levels of conventional risk factors and the global risk. Conclusions. Conventional coronary risk factors play an especially important role in the etiology of CHD in lupus patients. The accelerated atherosclerosis in SLE could be mediated by conventional coronary risk factors, which are affected by both lupus disease activity and corticosteroid therapy.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".