Research in the domain of nocturnal home hemodialysis (NHD): long-term clinical outcomes of NHD patients compared to conventional hemodialysis (CHD) patients post-renal transplantation
Bibliographic record
Abstract
Nocturnal home hemodialysis (NHD) is a novel type of renal replacement therapy (RRT) whereby patients administer their own dialysis on 5 to 7 nights per week, each session lasting between 5 and 8 hours. NHD is known to effectively reverse and even normalize many of the physiological aberrations of uremia. However, at present, renal transplantation remains the gold standard RRT and NHD patients continue to be referred for transplantation. Unfortunately, on account of such small numbers of patients undergoing NHD worldwide, little is known about the short- and long-term clinical outcomes of NHD patients after kidney transplantation. It was hypothesized that the incidence of delayed graft function (DGF), patient and graft survival, and post-transplant estimated glomerular filtration rate (eGFR), is better among conventional hemodialysis (CHD)-transplanted individuals than among those having received NHD. Of 231 past and current NHD patients in the Toronto NHD program, 36 underwent renal transplantation between January 1, 1994 and October 31, 2006. These 36 patients were matched to 68 transplanted CHD patients with a maximum follow-up of 11.7 years to test these hypotheses in the setting of a retrospective cohort study. The incidence of DGF was not significantly greater in the NHD group than in the CHD group [NHD: 15/35 (42.9%) vs. CHD: 25/68 (36.8%) p = 0.43] with an unadjusted OR of 1.41 (95% CI 0.60-3.27). Estimated (e)GFR was predicted by pre-transplant weight, donor age and recipient race; and assessed at baseline; at 1, 3, 6, and 12 months post-transplantation; and annually thereafter. Dialysis modality prior to transplantation did not influence the level of eGFR post-transplantation (p = 0.34), nor the rate of eGFR decline. Post-transplant hemoglobin was also not affected by pre-transplant dialysis modality (p = 0.12). Post-transplant systolic blood pressure was 4.8 mmHg lower in the CHD group (p = 0.04), though these patients were receiving signifi
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".