METABOLIC EFFECTS OF R-1,3-BUTANEDIOL (KETONE-IQ) DURING AEROBIC AND ANAEROBIC EXERCISE BOUTS
Bibliographic record
Abstract
Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 1, 2025. BACKGROUND: Current evidence demonstrates the efficacy of low carbohydrate/high fat ketogenic diets as it related to exercise. Exogenous ketone supplements have made it possible to ingest ketone molecules, elevating blood b-hydroxybutyrate (BHB) despite consuming carbohydrates (CHO). The purpose of this investigation was to determine both metabolic and performance effects of R-1,3-butanediol (BDO). METHODS: A randomized repeated measures placebo-controlled design was used to compare BDO and placebo (PLA). Each phase of testing utilized two primary testing days: 1) a dose exposure day designed to determine blood metabolite changes following consumption of BDO or PLA, 2) A performance day designed to assess the aerobic and anaerobic performance. In brief, dose exposure day consisted of a fasting baseline blood analysis followed by additional blood analysis at 20- and 40-minute post ingestion timepoints. Performance testing consisted of ingestion of 0.5g/kg of BDO or PLA and a standard meal (31g CHO, 2.5g fat, 13g protein). Participants then conducted a 5k time-trial on a treadmill while breath gases were analyzed. BHB and glucose (GLU) were determined at baseline, midpoint and post run. Following aerobic testing participants completed a repeated cycle test consisting of five 10-second sprints against resistance (7.5% body mass). STATISTICAL ANALYSES: Repeated measures analysis of variance (ANOVA) were conducted to establish group and time effects. RESULTS: BDO resulted in increased BHB relative to PLA at all time-points following baseline on the dose exposure day (20-minute p<0.001 and 40-minute). On the performance day, significant increases in BHB were also observed for all time-points for aerobic (p<0.001 for each) and anaerobic testing (Midpoint: p<0.01, Post: p<0.01). BDO supplementation resulted in significantly higher average power and average peak power outputs across the five 10-second cycle sprints. Additionally, supplementation resulted in significantly less fatigue as determined by Fatigue Index. A significant decrease in BHB for BDO, from pre-run (1.9±0.2mmol) to post-run (1.2±0.2mmol), was also observed (p=0.003). CONCLUSION: Acute supplementation with a novel ketone supplement significantly increases blood ketones and significantly improved anaerobic performance on a repeated cycle ergometer assessment. Funding: Health Via Modern Nutrition (HVMN)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".