The neural circuitry of pain as explored with functional MRI
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Since the discovery in the early 1990s that magnetic resonance imaging (MRI) can be used for functional imaging of the human brain, the technique has been used to examine the contribution of thalamic and cortical areas to the human pain experience. In a series of studies in this laboratory, functional MRI (fMRI) of noxious heat-, cold-, and median nerve stimulation-evoked activations demonstrated the involvement of the thalamus and multiple cortical areas in pain. The cortical areas identified included the primary and secondary somatosensory cortex (S1, S2), the anterior insula and the anterior cingulate cortex. The data also revealed a significant intersubject variability in the activation of any one of these regions, particularly during heat- and cold-evoked pain. These findings revealed the widespread cortical regions that are recruited by a noxious stimulus and provide clues to the neural circuitry of pain that undoubtedly include sensory, motor and cognitive components.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it