Differential calcineurin/NFATc1‐c3 signaling in the regulation of the skeletal muscle fiber phenotype
Bibliographic record
Abstract
Involvement of Cn/NFAT signaling in the regulation of the skeletal muscle fiber phenotype is recognized, however, the role of the various Cn‐regulated NFAT isoforms in this process remains rudimentary. We thus assessed the expression, localization and function of NFAT isoforms in muscle fibers of wild type or transgenic NFATc2 or NFATc3 deficient mice under normal weightbearing or functional compensatory work overload conditions. Immunohistochemical analyses indicated that NFAT isoforms have distinct roles in the regulation of muscle remodeling associated with compensatory growth. Semi‐quantitative RT‐PCR did not reveal compensatory up‐regulation of surviving NFAT isoform mRNA levels in transgenic mice. On the other hand, western blotting and immunofluorescence data showed NFAT protein localization to be differentially regulated during compensatory growth. Moreover, gene array analyses showed distinct gene expression patterns across conditions. Taken together, these results show that members of the NFAT family of transcription factors have distinct roles in the expression of the muscle fiber phenotype and a limited capacity to substitute for one another during conditions of rapid fiber growth. Supported by NSERC, CIHR and CRC to RNM. EMK is a CIHR scholar.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".