Investigating the functional biology of IL-25 during helminth infection (38.6)
Bibliographic record
Abstract
Abstract Recent studies have demonstrated key functions of interleukin (IL) -25 in TH2 cytokine-mediated host protective immunity and exacerbation of allergic airway inflammation, however the cell lineages targeted by IL-25 to elicit such responses remains unclear. We show that IL-25 acts through an innate cell mechanism to drive TH2 cytokine responses. Utilizing IL-4/eGFP reporter mice that express green fluorescent protein (GFP) under the IL-4 loci, we demonstrated that IL-25 specifically induced a c-kit+ cell population in the mesenteric lymph nodes. This population was also present in the Peyer’s patches, cecal patch, and peritoneum of treated mice. Despite displaying a cell morphology similar to classical mast cells, the IL-25-induced c-kit+ cell population lacked expression of FcεR1 and surface bound IgE. Additionally, IL-25 elicited a TH2 cytokine response and induced this c-kit+ cell population independently of IL-3 and SCF signaling, pathways known to regulate mast cell development. Furthermore, we demonstrated that in mice deficient in the receptor for IL-25 or IL-17A, IL-17Rb and IL-17Ra respectively, the IL-25-mediated induction of this c-kit+ population was lost. Thus, these data suggest that IL-25 acts through a mast-cell independent mechanism to promote TH2 cytokine responses, which is dependent on both IL-17Ra and IL-17Rb.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".