Ocular Delivery Of Ketotifen Fumarate By Silicone Hydrogel And Conventional Hydrogel Contact Lens Materials
Bibliographic record
Abstract
24 hour uptake period for commercially available daily disposable lenses: () ocufilcon B, (q) etafilcon A (1 Day Moist), (¢) narafilcon A, (u) filcon II 3, (p) omafilcon A and (A) nelfilcon A. Values plotted are means ± standard deviations. Figure 2c: Cumulative release of ketotifen fumarate over the 24 hour release period for commercially available daily disposable lenses: () ocufilcon B, (q) etafilcon A (1 Day Moist), (¢) narafilcon A, (u) filcon II 3, (p) omafilcon A and (A) nelfilcon A. Values plotted are means ± standard deviations. Figure 1b: Cumulative uptake of ketotifen fumarate over the 24 hour uptake period for commercially available silicone hydrogel lenses: () balafilcon A, (q) lotrafilcon B, (¢) galyfilcon A, (u) senofilcon A and (p) comfilcon A. Values plotted are means ± standard deviations. Figure 2b: Cumulative release of ketotifen fumarate over the 24 hour release period for commercially available silicone hydrogel lenses: () balafilcon A, (q) lotrafilcon B, (¢) galyfilcon A, (u) senofilcon A and (p) comfilcon A. Values plotted are means ± standard deviations. Figure 1a: Cumulative uptake of ketotifen fumarate over the 24 hour uptake period for commercially available conventional lenses: () etafilcon A (Acuvue2), (q) alphafilcon A and (¢) polymacon. Values plotted are means ± standard deviations. Figure 2a: Cumulative release of ketotifen fumarate over the 24 hour release period for commercially available conventional lenses: () etafilcon A (Acuvue2), (q) alphafilcon A and (¢) polymacon. Values plotted are means ± standard deviations. •Etafilcon A lenses, ocufilcon B and balafilcon A showed the greatest uptake and release of ketotifen after 24 hours. •Varying the concentration of the doping solution does have an effect on the total ketotifen taken up and released. •The recommended dosage schedule when using a 0.025% ketotifen ophthalmic solution is 2 drops per eye per day, or 25μg of per day. All the contact lenses tested released more than this amount, which means these lenses are capable of taking up and releasing a potentially clinically significant amount of ketotifen. •These lenses, however, release their loaded ketotifen very quickly, as is apparent in Figures 2a-c, generally reaching release plateaus after one to three hours. This limitation would seem to prevent this drug delivery system from being used with extended wear contact lenses. •However, the method of drug loading employed in this study may be sufficient for a daily disposable wear modality. Ocular Delivery Of Ketotifen Fumarate By Silicone Hydrogel And Conventional Hydrogel Contact Lens Materials #6101 A. Soluri, A. Hui, L. Jones
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".