Higher syncope burden is associated with poor cognitive function in an older adult population study
Bibliographic record
Abstract
Purpose: To examine the cognitive performance of subjects according to history and burden of syncope and non-accidental falls, in an unselected population representative sample. Methods: 5849 participants of the Irish longitudinal study on ageing (TILDA) were studied. Past history and recent burden of syncope and non-accidental falls were assessed during home interviewing. Cognitive performance was assessed during health assessment using the Montreal cognitive assessment (MOCA) score. Poor performance was defined as scoring in the lowest decile of MOCA scores. Multivariate analysis controlling for potential confounders was carried out to compare cognitive performance by syncope status. Results: In this Irish population (n=5849), mean age 63±9 (54% women), a past history of syncope (in youth only or in adulthood only) was more common in subjects with higher cognitive performance. However, recent burden of syncope (in the past 12 months) was higher in subjects with lower cognitive performance (5.3% vs 3.5%; P=0.04), specifically multiple events of syncope (2.8% vs 1.6%; P=0.01). The prevalence of non-accidental falls was higher in those with lower cognition (10.4% vs 4.7%; P<0.0001). Multivariate analysis adjusted for age, sex and education indicated that subjects with syncope in adulthood only had a lower odds of poor cognitive performance (OR=0.68, 95% CI=0.5, 0.95), whereas subjects reporting multiple events of syncope in the last year had an increased odds of poor cognition (OR=1.77, 95% CI=1, 3.12). Subjects with non-accidental falls in the last year were also at greater odds of scoring poorly (OR=1.55, 95% CI=1.12, 2.14). Both associations remained significant following additional adjustment for clinical profile, behavioural health, depression, cardiovascular disease and medication use. Conclusion: Recent burden of syncope and non-accidental falls were each independently associated with lower cognitive performance, in a large population based sample of older adults. Further studies are warranted to investigate the causality of this relationship. Our study highlights the potential importance of syncope in the context of cognition.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".