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New Insights into Biosynthesis of Cuticular Wax

2015· article· en· W836314961 on OpenAlexaff
Ljerka Kunst

Bibliographic record

VenueThe FASEB Journal · 2015
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicPlant Surface Properties and Treatments
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsWaxCutinArabidopsisCuticle (hair)BiochemistryPlant cuticleMutantBiologyFatty acidEnzymeYeastBiosynthesisChemistryCell biologyGeneGenetics

Abstract

fetched live from OpenAlex

The outer epidermal cell walls of plant shoots are covered with a cuticle, a continuous lipid structure that protects plants from desiccation, UV‐light, pathogens, and insects. The cuticle is composed of cutin polymer matrix embedded and coated with waxes. Major wax components are derived from very‐long‐chain fatty acid (VLCFA) precursors with chain lengths between C24 and C34. We are taking advantage of wax‐deficient eceriferum (cer) mutants in Arabidopsis to identify and functionally characterize gene products involved in wax biosynthesis, wax export to the cuticle, and regulation of these processes. I will describe our work on the cer2 mutant, which resulted in the identification of a novel component of fatty acid elongation machinery required for the extension of acyl chains beyond C28. This process is unique to plants where C30‐C34 VLCFAs are used for the production of cuticular wax and the pollen coat, critical for pollen hydration. The core VLCFA elongation complex involves four proteins. Condensing enzymes catalyze the first elongation reaction and determine the chain length of fatty acid products. While necessary for the production of all VLCFAs, known condensing enzymes cannot produce VLCFAs longer than C28. Heterologous expression in yeast revealed that CER2 protein could modify the chain‐length specificity of a condensing enzyme, CER6, from C28 to C30. We identified two CER2 homologs in Arabidopsis. Results of our investigation of the specificities and physiological roles of this protein family will be discussed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.003
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.208
Teacher spread0.172 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2015
Admission routes1
Has abstractyes

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