Ubisol‐Q halts the progression of parkinsonian neurodegeneration in rodent models of Parkinson's disease
Bibliographic record
Abstract
Coenzyme Q10 is a candidate for neuroprotection in Parkinson's disease (PD), in which both energy failure and oxidative stress are responsible for its progressive nature. The low therapeutic efficacy of CoQ10 in clinical trials of PD may be due to its insolubility in aqueous media, poor bioavailability and penetration into the brain. We have developed a technology to solubilize CoQ10 in water (Ubisol‐Q) in order to increase its therapeutic potential. Oral administration of Ubisol‐Q, containing PTS TM and CoQ10, elevated plasma and brain levels of both CoQ10 and vitamin E, in rats and mice. A prophylactic application of Ubisol‐Q (48 mg/kg/day or 6 mg/kg/day) in rodent models of PD (MPTP and paraquat) revealed a near complete protection of dopamine neurons. A therapeutic application of Ubisol‐Q, started immediately after the initiation of neuronal injury, protected dopamine neurons and preserved dopamine nerve terminals in both models of PD. Ubisol‐Q also resulted in a marked improvement in motor function of mice and rats performing on a beam walk test. The results of these pre‐clinical studies are highly encouraging and suggest that Ubisol‐Q, at lower doses than other CoQ10 products, has improved bioavailability and superior therapeutic efficacy and could be used as an adjuvant therapy in the management of PD. Ubisol‐Q is GRAS and will be tested clinically. Funding by MJFF and Zymes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".