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Establishing an Anatomical Proximity Between the Coronary Circumflex Artery and the Mitral Valve Annulus: Implications for Mitral Valve Surgery

2015· article· en· W873003219 on OpenAlexaff
Eliot Winkler, Bayan Malakouti‐Nejad, Marjorie Johnson, Jorge Catrip, Jeevan Nagendran, Michael Chu

Bibliographic record

VenueThe FASEB Journal · 2015
Typearticle
Languageen
FieldMedicine
TopicCardiac Structural Anomalies and Repair
Canadian institutionsLondon Health Sciences CentreWestern University
Fundersnot available
KeywordsMedicineMitral valveCadaveric spasmAnnulus (botany)CardiologyCircumflexAnatomyCommissureInternal medicineMitral annulusCoronary sinusFibrous jointArteryDiastoleBlood pressureBiology

Abstract

fetched live from OpenAlex

The coronary circumflex artery (CX) lies in the left atrioventricular groove, running intimately parallel to the mitral valve annulus. Thus, unintentional damage to the CX can occur via a fixation suture during mitral valve surgery, typically reported in hearts with a left dominant or co‐dominant circulation. This study aims to elucidate the anatomical relationship between the CX and annulus, and evaluate damage to the CX following three different mitral valve surgical repairs. It is predicted that left dominant or co‐dominant hearts should exhibit the closest anatomical relationship between the CX and annulus and experience a greater incidence of damage despite the chosen mitral valve surgery. Using fixed (n=18) and fresh‐frozen (n=9) cadaveric hearts, coronary circulation was dissected and dominance determined. After opening the left atrial wall, a clock face was overlaid on the mitral valve (12:00 position at the A2 leaflet midline) and the distance between the annulus and the CX was measured at each hour. The CX was closest to the annulus in fresh‐frozen, left dominant hearts. All left dominant and co‐dominant hearts had CXs that hugged the posterior length of the annulus, diving deep at 3:00 (before the posterior commissure), a finding previously unreported. Preliminary results from the ongoing surgical repairs advocate for cautionary suture placement in areas formerly considered to be at low risk for damage.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.036
Threshold uncertainty score0.627

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.002
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.050
GPT teacher head0.295
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2015
Admission routes1
Has abstractyes

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