A Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions as Bad Actors
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Bibliographic record
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTA Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions as Bad ActorsSteven W. M. Crossley and Ryan A. Shenvi*View Author Information Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 17, 9465–9531Publication Date (Web):July 9, 2015Publication History Received16 March 2015Published online9 July 2015Published inissue 9 September 2015https://pubs.acs.org/doi/10.1021/acs.chemrev.5b00154https://doi.org/10.1021/acs.chemrev.5b00154review-articleACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views6832Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Chemical synthesis,Organic compounds,Organic synthesis,Pyrroles Get e-Alerts
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.006 | 0.002 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.009 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it