Bibliographic record
Abstract
Intestinal epithelial barrier function is critical to host protection against pathogens, and it is one of the first defence mechanisms affected in gastrointestinal disease. Barrier function is maintained by a three part system involving bacteria and host proteins in the intestinal lumen, the mucus layer and peptides embedded in it, and intestinal epithelial cells and tight junctions between them. Together these components act synergistically to maintain barrier function, and a change in any of these may result in increased permeability to pathogens and antigenic stimuli, and aberrant activation of immune cells. The intestinal mucus layer, at the centre of this system is critical to the proper functioning of all components. These studies illustrate that in the absence of an intact mucus layer, intestinal barrier function is compromised, disease susceptibility is increased and recovery following injury delayed. These studies also investigated whether or not susceptibility to dextran sulfate sodium induced colitis could be modulated with probiotics. In addition, the functional roles of an intact mucus layer in Entamoeba histolytica-induced acute inflammatory and permeability responses in the colon were examined. Probiotic therapy using VSL#3 was ineffective at limiting injury or accelerating colonic healing. The data presented here illustrate that Muc2-/- animals were highly susceptible to E. histolytica induced secretory responses through altered expression of various tight junction proteins. These findings unravel a novel role for MUC2 mucin in conferring both luminal and epithelial barrier functions critical in innate host defence against intestinal infection and wound healing.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".