<i>Birc1e/Naip5</i>in Macrophage Function and Susceptibility to Infection with<i>Legionella pneumophila</i>
Why this work is in the frame
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Bibliographic record
Abstract
Genetic analysis in the mouse has been used to identify host genes and proteins that play important roles in natural defences against a broad range of infectious diseases. In mouse, susceptibility to infection with Legionella pneumophila is genetically controlled. Intracellular pathogens have evolved different strategies to inhibit or escape the bacteriostatic or bactericidal defense mechanisms of host macrophages. Electron microscopy studies indicated that Legionella-containing phagosome (LCP) morphology diverges from classic phagosomes: within the first 5 min of infection, LCPs become surrounded by host vesicles; 15 min postinfection, the thickness of the phagosomal membrane resembles that of the endoplasmic reticulum (ER), and 6 h after infection, ribosomes are found attached to the cytoplasmic face of LCPs. Nontransgenic permissive A/J peritoneal and bone marrow-derived macrophages allowed massive L. pneumophila replication over a 72-h infection period (2.8 ± 0.3 and 1.6 ± 0.4 log CFU respectively) compared to macrophages from Birc1e/Naip5-resistant transgenic animals (0.74 ± 0.18 and -0.52 ± 0.26 log CFU respectively). It has been proposed that, like other members of the NLR family, Birc1e/Naip5 may function as an intracellular sensor of L. pneumophila products and may trigger immune responses through inflammatory caspases.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it