Expression Of Epithelial Sodium Channel (ENaC) And Its Regulatory Genes In Brain Of Dahl S And R Rats On High Salt Diet.
Bibliographic record
Abstract
Central blockade of ENaC or MR prevents sympathoexcitation and hypertension in Dahl S rats on high salt diet. We assessed the effects of high salt on expression of ENaC and its regulators ie‐ MR, SGK1, as well as aldosterone synthase (AS) and 11 β HSD2 mRNA in brain areas of S and R rats. 4 weeks old Dahl S and R rats were placed on regular (0.3%) or high (8%) salt diet for 2 and 4 weeks. mRNA expression was measured by real time RT‐PCR. In the choroid plexus (CP) and PVN, ENaC subunits transcription was not affected by salt intake. 2 weeks high salt diet increased SGK1 mRNA in CP of both strains and in PVN of only S rats. In the SON, high salt significantly increased β ENaC and SGK1 mRNA in S rats at 2 weeks and tended to increase at 4 weeks. Expression of γ ENaC and 11 βHSD2 in SON were increased by high salt in both strains at 2 weeks, persisted to be increased only in S rats at 4 weeks. Salt intake did not affect MR and AS expression. High salt induced increase in SGK1 and ENaC expression in brain areas such as SON of S rats may increase ENaC activity and thereby enhance neuronal excitability leading to sympathoexcitation and hypertension.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".