Hyperosmolar sucrose protects against acid‐induced lung injury in awake rats
Bibliographic record
Abstract
We reported that in the anaesthetized rat, transient plasma hyperosmolarity confers 2‐hour protection against lung injury following intra‐tracheal acid instillation ( AJRCCM 2005 ; 172 : 1002 – 7 ). Here, we considered the extent of hyperosmolar protection over a longer post‐injury period. We anesthetized (ketamine (50 mg/kg)+xylazine; 5 mg/kg, i.p.) rats (Sprague‐Dawley, 400 g) (n=9). Then, by per‐oral endotracheal intubation, we intra‐tracheally instilled saline, or acid (0.1N HCl, pH 1.2) at 2 ml/kg. After 30 min, we infused into the femoral vein either isoosmolar buffer (310 mosm), or sucrose (1500–1600 mosm; 4 ml/kg) for 15 min. The animals regained consciousness in ~1 h. After 6 h, we again anesthetized the rats and we removed the lungs through a thoracotomy for determination of the extravascular lung water (EVLW) content. In saline‐instilled rats, EVLW of 3.6±0.04 g/g dry was similar to that of control, non‐instilled rats. In acid‐instilled rats, for the buffer‐infused group EVLW was 60 % higher than control, but for the sucrose‐infused group EVLW was not different from control (P<0.05). We conclude that a 15‐min intravenous infusion of hyperosmolar sucrose given shortly after intra‐tracheal acid instillation protects against lung injury for up to 6 hours (Support: HL36024, HL57556).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".