Lifetime consumption of a low vitamin K diet leads to learning impairment in aged rats: potential links with sphingolipid metabolism
Bibliographic record
Abstract
In a recent report, we showed VK to preferentially accumulate in brain regions rich in white matter and to positively correlate with certain sphingolipids. In rodents, pharmacological VK deficiency has resulted in behavioral perturbations. Whether a more physiological deficiency leads to similar effects has not yet been determined. To gain insight on this issue, we investigated learning abilities (Morris water maze) in 6, 12 and 20 month‐old female SD rats which had been fed diets containing either very low (VL: 80), low (L: 500) or moderately high (H: 2000) levels of K1 (μg/Kg diet; n=5–10/group) since weaning. In 20‐months rats, cerebroside, sulfatide, sphingomyelin, ceramide and gangliosides were also assessed in cerebellum, midbrain, pons medulla, striatum and hippocampus (Bodennec et al. Meth. Enzymol. 312:101–14, 2000). Lifetime consumption of a low VK diet led to cognitive deficits in old age, rats from VL group showing longer latencies to reach the platform than those from the L and H groups (p<0.05), a finding associated with higher concentrations of ceramides in the hippocampus and lower gangliosides in the pons medulla and midbrain. Learning abilities at 6 or 12 months were not affected by diet. In conclusion, we show for the first time that lifetime consumption of a low VK diet leads to learning impairments in old age and that this may be linked to disturbances in sphingolipid metabolism. Supported by NSERC.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".