Lymphoma cell surface expression of CD200 modulates anti‐tumor immunity
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
CD200 is a transmembrane protein broadly expressed on a variety of cell types and delivers immunoregulatory signals through binding to receptor (CD200Rs) expressed on monocyte/myeloid cells and T lymphocytes. We showed in earlier reports that infusion of a soluble form of CD200, CD200Fc, into EL4 thymoma‐bearing C57/B6 mice enhanced tumor progression (Clin. Exp. Immunol. 2001). More recently, independent groups have reported CD200 overexpression associated with multiple myeloma, AML, and CLL. In this study we investigated the in vitro effect of blockade of CD200 expression, using both anti‐CD200 mAbs and CD200‐specific siRNAs, on CTL induction in human PBL using a CD200+ lymphoma cell line (ly5). We found that blockade of CD200 on ly5 cells significantly enhanced anti‐tumor CTL responses in vitro. Production of the inflammatory cytokines TNFa and IFNg were similarly enhanced. Cell depletion studies supported an important role for antigen presenting cells in CD200 regulation of anti‐tumor responses. We also developed a CD200 ELISA assay to measure serum CD200 levels in healthy donor controls and cancer patients, and in preliminary analyses found elevated levels of sCD200 in the plasma of patients with CLL. Our data provide novel insights into the mechanisms of CD200 mediated suppression of tumor immunity, the understanding of which may open new avenues to development of different cancer therapies.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it