← Retour à la cohorte
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Niamh Mullins, Jooeun Kang, Adrián I. Campos, Jonathan R. I. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey A. Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark J. Adams, Michael J. Gandal, Jonathan D. Hafferty, Akitoyo Hishimoto, Minsoo Kim, Satoshi Okazaki, Ikuo Otsuka, Erin B. Ware, Andrew W. Bergen, Martin Bohus, Harry Brandt, Xiao Chang, Wei J. Chen, Hsi‐Chung Chen, Steven Crawford, Scott J. Crow, Emily DiBlasi, Philibert Duriez, Fernando Fernández‐Aranda, Manfred M. Fichter, Steven Gallinger, Stephen J. Glatt, Philip Gorwood, Yiran Guo, Hakon Hakonarson, Katherine A. Halmi, Hai‐Gwo Hwu, Sonia Jain, Stéphane Jamain, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, Kelly L. Klump, Shih‐Cheng Liao, Klaus Lieb, Chih‐Min Liu, Christian R. Marshall, James E. Mitchell, Eric T. Monson, Dalila Pinto, Abigail Powers, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Michael Strober, Laura M. Thornton, Janet Treasure, Ming T. Tsuang, Stephanie H. Witt, D. Blake Woodside, Zeynep Yılmaz, Rolf Adolfsson, Tracy Air, Martin Alda, Ole A. Andreassen, Adebayo Anjorin, Vivek Appadurai, María Soler Artigas, M.H. Azevedo, Nicholas Bass, Claiton H.D. Bau, Bernhard T. Baune, Frank Bellivier, Klaus Peter Berger, Joanna M. Biernacka, Tim B. Bigdeli, Michael Boehnke, Marco P. Boks, Rosa Bosch, David Braff, Richard A. Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Miguel Casas, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Aiden Corvin, Nicholas Craddock, David W. Craig, Srdjan Djurovic, Howard J. Edenberg, Ayman H. Fanous, Jerome C. Foo, Andreas J. Forstner, Mark A. Frye, Justine M. Gatt, Pablo V. Gejman, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugênio H. Grevet, Maria Grigoroiu‐Serbânescu, Blanca Gutiérrez, José Guzmán‐Parra, Marian L. Hamshere, Annette M. Hartmann, Joanna Hauser, Stefanie Heilmann‐Heimbach, Marcus Ising, Ian Jones, Lisa Jones, Lina Jönsson, René S. Kahn, John R. Kelsoe, Stefan Kloiber, Karestan C. Koenen, Bettina Konte, Marie‐Odile Krebs, Mikael Landén, Marion Leboyer, Douglas F. Levinson, Susan L. McElroy, Patrick J. McGrath, Andrew McQuillin, Divya Mehta, Ingrid Melle, Yuri Milaneschi, Philip B. Mitchell, Esther Molina, Preben Bo Mortensen, Caroline M. Nievergelt, Vishwajit L. Nimgaonkar, Markus M. Nöthen, Michael O‘Donovan, Roel A. Ophoff, Brenda W.J.H. Penninx, Jonathan Pimm, Giorgio Pistis, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos‐Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Andrea L. Roberts, Gloria Roberts, Guy A. Rouleau, Diego Luiz Rovaris, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Stanley I. Shyn, Pamela Sklar, Edmund Sonuga‐Barke, Gianfranco Spalletta, John S. Strauss, Beata Świątkowska, Maciej Trzaskowski, Gustavo Turecki, Laura Vilar‐Ribó, Henry Völzke, James Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Clement C. Zai, Allison E. Ashley‐Koch, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser, Nathan A. Kimbrel, Jennifer H. Lindquist, Benjamin H. McMahon, David W. Oslin, Xuejun Qin, Stephan Ripke, Manuel Mattheisen, Abdel Abdellaoui, Till F. M. Andlauer, Silviu‐Alin Bacanu, Marie Bækvad‐Hansen, Aartjan T.F. Beekman, Henriette N. Buttenschøn, Jonas Bybjerg‐Grauholm, Na Cai, Jane Christensen, Toni‐Kim Clarke, Lucía Colodro‐Conde, Baptiste Couvy‐Duchesne, Nick Craddock, Gregory E. Crawford, Gail Davies, Franziska Degenhardt, Eske M. Derks, Neşe Direk, Conor V. Dolan, Erin C. Dunn, Thalia C. Eley, Valentina Escott‐Price, Farnush Farhadi Hassan Kiadeh, Hilary K. Finucane, Josef Frank, Héléna A. Gaspar, Michael Gill, Fernando S. Goes, Scott D. Gordon, Shantel Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Yang Wu, Hualin Simon Xi, Jian Yang, Futao Zhang, Volker Arolt, Dorret I. Boomsma, Sven Cichon, Udo Dannlowski, Eco J. C. de Geus, J. Raymond DePaulo, Enrico Domenici, Katharina Domschke, Jakob Grove, Lynsey S. Hall, Thomas Folkmann Hansen, Stefan Herms, Ian B. Hickie, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David M. Hougaard, David M. Howard, Rick Jansen, Eric Jorgenson, Isaac S. Kohane, Julia Kraft, Warren W. Kretzschmar, Zoltán Kutalik, Yihan Li, Penelope A. Lind, Donald J. MacIntyre, Dean F. MacKinnon, Robert Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Sarah E. Medland, Christel M. Middeldorp, Evelin Mihailov, Francis M. Mondimore, Sara Mostafavi, Matthias Nauck, Bernard Ng, Michel G. Nivard, Dale R. Nyholt, Paul F. O’Reilly, Högni Óskarsson, Caroline Hayward, Andrew C. Heath, Glyn Lewis, Qingqin S. Li, Pamela A. F. Madden, Patrik K. E. Magnusson, Nicholas G. Martin, Andrew M. McIntosh, Andres Metspalu, Ole Mors, Bertram Müller-Myhsok, Merete Nordentoft, Sara A. Paciga, Nancy L. Pedersen, Jodie N. Painter, Marianne Giørtz Pedersen, Roseann E. Peterson, Wouter J. Peyrot, Daniëlle Posthuma, Jorge A. Quiroz, Per Qvist, John P. Rice, Brien P. Riley, Saira Saeed Mirza, Robert A. Schoevers, Eva C. Schulte, Ling Shen, Engilbert Sigurðsson, Grant Sinnamon, Johannes H. Smit, Hreinn Stefánsson, Stacy Steinberg, Jana Strohmaier, Katherine E. Tansey, Henning Teismann, Alexander Teumer, Wesley K. Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G. Uitterlinden, Daniel Umbricht, Albert M. van Hemert, Alexander Viktorin, Peter M. Visscher, Yunpeng Wang, Bradley T. Webb, David J. Porteous, Marcella Rietschel, Catherine Schaefer, Kari Stefansson, Henning Tiemeier, Rudolf Uher, Thomas Werge, Cathryn M. Lewis, Anders D. Børglum, Kevin S. O’Connell, Brandon J. Coombes, Zhen Qiao, Thomas D. Als, Sigrid Børte, Julien Bryois, Alexander W. Charney, Ole Kristian Drange, Saskia P. Hagenaars, Masashi Ikeda, Nolan Kamitaki, Kristi Krebs, Georgia Panagiotaropoulou, Brian M. Schilder, Laura Sloofman, Bendik S. Winsvold, Hong‐Hee Won, Liliya Abramova, Kristina Adorjan, Esben Agerbo, Mariam Al Eissa, Diego Albani, Ney Alliey‐Rodriguez, Verneri Antilla, Anastasia Antoniou, Swapnil Awasthi, Ji Hyun Baek, Michael Bauer, Eva C. Beins, Sarah E. Bergen, Armin Birner, Erlend Bøen, Murielle Brum, Ben Brumpton, Nathalie Brunkhorst-Kanaan, William Byerley, Murray J. Cairns, Pablo Cervantes, Cristiana Cruceanu, Alfredo B. Cuéllar‐Barboza, Julie M. Cunningham, David Curtis, Piotr M. Czerski, Anders M. Dale, Nina Dalkner, Friederike S. David, Amanda Dobbyn, Torbjørn Elvsåshagen, I. Nicol Ferrier, Alessia Fiorentino, Tatiana Foroud, Liz Forty, Oleksandr Frei, Nelson B. Freimer, Louise Frisén, Katrin Gade, Julie Garnham, Joel Gelernter, Ian R. Gizer, Daniel J. Smıth, Tiffany A. Greenwood, Kyooseob Ha, Magnús Haraldsson, Martin Hautzinger, Urs Heilbronner, Dennis Hellgren, Peter Holmans, Laura M. Huckins, Jessica Johnson, János Kálmán, Sarah Kittel‐Schneider, Maria Koromina, Thorsten M. Kranz, Henry R. Kranzler, Michiaki Kubo, Ralph Kupka, Steven A. Kushner, Catharina Lavebratt, Markus Leber, Heon‐Jeong Lee, Shawn Levy, Martin Lundberg, Sigurður H. Magnússon, Adam X. Maihofer, Dolores Malaspina, Eirini Maratou, Lina Martinsson, Nathaniel W. McGregor, James McKay, Helena Medeiros, Vincent Millischer, Jennifer L. Moran, Derek W. Morris, Thomas W. Mühleisen, Niamh L. O’Brien, Claire O’Donovan, Loes M. Olde Loohuis, Lilijana Oruč, Sergi Papiol, Antonio F. Pardiñas, Amy Perry, Andrea Pfennig, Evgenia Porichi, James B. Potash, Towfique Raj, Mark Hyman Rapaport, Eline J. Regeer, Fabio Rivas, Julian Roth, Panos Roussos, Fanny Senner, Sally I. Sharp, Paul D. Shilling, Claire Slaney, Janet L. Sobell, Anne T. Spijker, Dan J. Stein, Chikashi Terao, Claudio Toma, Paul A. Tooney, Evangelia Eirini Tsermpini, Marquis P. Vawter, Helmut Vedder, Simon Xi, Wei Xu, Jessica Yang, Allan H. Young, Hannah Young, Peter P. Zandi, Hang Zhou, Gulja Babadjanova, Lena Backlund, Susanne Bengesser, Wade H. Berrettini, Douglas Blackwood, Vaughan J. Carr, Stanley V. Catts, Dimitris Dikeos, Bruno Étain, Panagiotis Ferentinos, Micha Gawlik, Elliot S. Gershon, Frans A. Henskens, Jan Hillert, Kyung Sue Hong, Christina M. Hultman, Kristian Hveem, Nakao Iwata, Assen Jablensky, George Kirov, Christine Löchner, Carmel M. Loughland, Carol A. Mathews, Francis J. McMahon, Patricia T. Michie, Bryan Mowry, Benjamin M. Neale, Caroline M. Nievergelt, Ketil J. Øedegaard, Tomas Olsson, Christos Pantelis, George P. Patrinos, Eva Z. Reininghaus, Takeo Saito, Ulrich Schall, Martin Schalling, Rodney J. Scott, Eystein Stordal, Fabian Streit, Eduard Vieta, Irwin D. Waldman, John‐Anker Zwart, John I. Nürnberger, Eli A. Stahl, Arianna Di Florio, Roger A.H. Adan, Lars Alfredsson, Tetsuya Ando, H.N. Aschauer, Jessica H. Baker, Vladimír Bencko, Andreas Birgegård, Joseph M. Boden, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Cynthia M. Bulik, Roland Burghardt, Laura Carlberg, Matteo Cassina, Maurizio Clementi, Roger D. Cone, Philippe Courtet, James J. Crowley, Unna N. Danner, Oliver S. P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Christian Dina, Monika Dmitrzak‐Węglarz, Elisa Docampo Martínez, Laramie E. Duncan, Karin Egberts, Morten Mattingsdal, Sara McDevitt, Ingrid Meulenbelt, Nadia Micali, John C. Mitchell, Karen S. Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Grant W. Montgomery, Melissa A. Munn‐Chernoff, Benedetta Nacmias, Marie Navratilova, Ιωάννα Ντάλλα, Catherine M. Olsen, Julie K. O’Toole, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papežová, Richard Parker, John F. Pearson, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Thomas Espeseth, Xavier Estivill, Anne Farmer, Angela Favaro, Krista Fischer, James Floyd, Manuel Föcker, Lenka Foretová, Monica Forzan, Christopher S. Franklin, Giovanni Gambaro, Johanna Giuranna, Paola Giusti-Rodríquez, Fragiskos Gonidakis, Monica Gratacos Mayora, Sébastien Guillaume, Ken B. Hanscombe, Konstantinos Hatzikotoulas, Johannes Hebebrand, Sietske G. Helder, Anjali K. Henders, Beate Herpertz‐Dahlmann, Wolfgang Herzog, Anke Hinney, L. John Horwood, Christopher Hübel, Liselotte Petersen, Kirstin L. Purves, Anu Raevuori, Ted Reichborn‐Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Filip Rybakowski, Paolo Santonastaso, André Scherag, Ulrike Schmidt, Nicholas J. Schork, Alexandra Schosser, Jochen Seitz, Lenka Šlachtová, P. Eline Slagboom, M Landt, Agnieszka Słopień, Nicole Soranzo, Sandro Sorbi, Lorraine Southam, Vidar W. Steen, James I. Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimír Janout, Jennifer Jordan, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Jaakko Kaprio, Leila Karhunen, Andreas Karwautz, Martien J. Kas, James L. Kennedy, Martin A. Kennedy, Anna Keski‐Rahkonen, Kirsty Kiezebrink, Youl‐Ri Kim, Katherine M. Kirk, Lars Klareskog, Gun Peggy Knudsen, Janne Tidselbak Larsen, Stéphanie Le Hellard, Virpi Leppä, Paul Lichtenstein, Bochao Lin, Jolanta Lissowska, Astri J. Lundervold, Jurjen J. Luykx, Mario Maj, Katrin Männik, Sara Marsal, Garret D. Stuber, Patrick F. Sullivan, Jin P. Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Άρτεμις Τσίτσικα, Marta Tyszkiewicz‐Nwafor, Konstantinos Tziouvas, Annemarie Elburg, Eric F. van Furth, Tracey Wade, Gudrun Wagner, Esther Walton, David C. Whiteman, H.‐Erich Wichmann, Elisabeth Widén, Shuyang Yao, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Martin Jungkunz, Lydie Dietl, Cornelia E. Schwarze, Norbert Dahmen, Björn H. Schott, Arian Mobascher, Dan Rujescu, Silvia Crivelli, Michelle F. Dennis, P.D. Harvey, Bruce W. Carter, Jennifer E. Huffman, Daniel Jacobson, Ravi Madduri, John Pestian, J. Michael Gaziano, Sumitra Muralidhar, Rachel Ramoni, Jean C. Beckham, Kyong‐Mi Chang, James L. Breeling, Grant D. Huang, Jonathan Romero, Jennifer Moser, Stacey B. Whitbourne, Jessica V. Brewer, Mihaela Aslan, Todd Connor, Dean P. Argyres, Philip S. Tsao, Brady Stephens, Mary T. Brophy, Donald E. Humphries, Luis E. Selva, Nhan Do, Shahpoor Shayan, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Hongyu Zhao, Peter W.F. Wilson, Rachel McArdle, Louis J. Dell’Italia, Kristin Mattocks, John B. Harley, Clement J. Zablocki, Jeff Whittle, Frank J. Jacono, Salvador Gutierrez, Gretchen Gibson, Kimberly Hammer, Laurence S. Kaminsky, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark B. Hamner, Roy O. Mathew, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair K. Ballas, Douglas Ivins, Stephen Mastorides, Jonathan P. Moorman, Saib Gappy, Jon Klein, Nora Ratcliffe, Hermes Flórez, Olaoluwa Okusaga, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Neeraj Tandon, Darshana Jhala, Samuel M. Aguayo, David Cohen, Satish Sharma, Suthat Liangpunsakul, Kris Ann Oursler, Mary A. Whooley, Sunil K. Ahuja, Joseph Constans, Paul Meyer, Jennifer Greco, Michael Rauchman, Richard J. Servatius, Melinda Gaddy, Agnes Wallbom, Timothy R. Morgan, Todd Stapley, Scott E. Sherman, George Ross, Patrick Strollo, Edward J. Boyko, Laurence Meyer, Samir Gupta, Mostaqul Huq, Joseph Fayad, Adriana M. Hung, Jack Lichy, Robin A. Hurley, R. Brooks Robey, Rob Striker, Annette Erlangsen, Ronald C. Kessler, David J. Porteous, Robert J. Ursano, Danuta Wasserman, Hilary Coon, Ditte Demontis, Anna R. Docherty, Po‐Hsiu Kuo, J. John Mann, Miguel E. Rentería, Murray B. Stein, Virginia L. Willour
Notice bibliographique
RevueBiological Psychiatry · 2021
Typearticle
Langueen
DomainePsychology
ThématiqueSuicide and Self-Harm Studies
Établissements canadiensMcGill UniversityMontreal Neurological Institute and HospitalUniversity of TorontoUniversity Health NetworkDalhousie UniversityHospital for Sick ChildrenCentre for Addiction and Mental Health
Organismes subventionnairesCilagNational Institute on Alcohol Abuse and AlcoholismStatens Serum InstitutInstituto de Salud Carlos IIINIHR Maudsley Biomedical Research CentreInstitute of Psychiatry, Psychology and Neuroscience, King’s College LondonCampbell Family Mental Health Research InstituteVeterans Affairs San Diego Healthcare SystemUniversité de ParisNeuraxpharmCentro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y NutriciónMedical Research CouncilServierUniversitat Autònoma de BarcelonaDiakonhjemmetH. Lundbeck A/SHospital for Sick ChildrenDivision of Materials ResearchCentre National de la Recherche ScientifiqueUniversitat de BarcelonaUniversité Paris DiderotUniversitetet i OsloSchool of MedicineUniversidade Federal do Rio Grande do SulUmeå UniversitetNational Center for Advancing Translational SciencesKaiser PermanenteSaint Petersburg State UniversityCentre Hospitalier Universitaire VaudoisCollege of Engineering, Michigan State UniversityDalhousie UniversityVA Pittsburgh Healthcare SystemState University of New YorkQueensland University of TechnologyInstitut National de la Santé et de la Recherche MédicaleGentofte HospitalNational Institute for Health and Care ResearchFresenius Medical Care North AmericaU.S. Department of Veterans AffairsGW PharmaceuticalsNIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer ResearchACADIA PharmaceuticalsEmory UniversityJazz PharmaceuticalsWellcome TrustSunovionIndiviorAarhus UniversitetNational Institute of Mental HealthHospital de Clínicas de Porto AlegreUniversité de LausanneLundbeckfondenEli Lilly and CompanyKing Abdullah University of Science and TechnologyVanderbilt UniversityKarolinska InstitutetNational Institute of General Medical SciencesNational Alliance for Research on Schizophrenia and DepressionFlorida State UniversityAmerican Society of Clinical PsychopharmacologyMichigan State UniversityState University of New York Upstate Medical UniversityPfizerBrain and Behavior Research FoundationNational Institutes of HealthSyracuse UniversityUniversidade de CoimbraUniversity of Toronto
Mots-clésGenetic architecturePsychiatryPsychologyMedicineEnvironmental health
Résumé
BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
score de la tête « metaresearch » (Codex)0,002
score de la tête « metaresearch » (Gemma)0,004
Version: metacan-v3-hybrid-931329e0061cStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Observationnel · Signal consensuel: Observationnel
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,005
Score d'incertitude au seuil0,009
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
Tête enseignante Opus0,030
Tête enseignante GPT0,298
Écart entre enseignants0,268 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validation
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeObservationnel
Domainenon disponible
GenreEmpirique
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».
En bref
Citations247
Publié2021
Routes d'admission2
Résumé présentnon