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Enregistrement W4224277562 · doi:10.1101/2022.04.18.22273968

Coding Long COVID: Characterizing a new disease through an ICD-10 lens

2022· preprint· en· W4224277562 sur OpenAlexfundno aff
Emily Pfaff, Charisse Madlock‐Brown, John M. Baratta, Abhishek Bhatia, Hannah Davis, Andrew T. Girvin, Elaine Hill, Liz Kelly, Kristin Kostka, Johanna Loomba, Julie A. McMurry, Rachel Wong, Tellen D. Bennett, Richard A. Moffitt, Christopher G. Chute, Melissa Haendel

Notice bibliographique

RevuemedRxiv · 2022
Typepreprint
Langueen
DomaineMedicine
ThématiqueLong-Term Effects of COVID-19
Établissements canadiensnon disponible
Organismes subventionnairesInstitute for Clinical and Translational Science, University of California, IrvineNational Center for Advancing Translational SciencesClinical and Translational Science Institute, Boston UniversitySouth Carolina Clinical and Translational Research Institute, Medical University of South CarolinaCenter for Clinical and Translational Sciences, University of Texas Health Science Center at HoustonCenter for Clinical and Translational Science, Mayo ClinicColorado Clinical and Translational Sciences InstituteCenter for Clinical and Translational Science, University of MassachusettsUniversity of Colorado DenverCenter for Clinical and Translational ResearchLeonard M. Miller School of MedicineUniversity of California, IrvineOregon Clinical and Translational Research InstituteUniversity of California, DavisWeill Cornell Medical CollegeUniversity of Illinois at Urbana-ChampaignNational Institutes of HealthUniversity of California, San FranciscoLouisiana Clinical and Translational Science CenterTufts Medical CenterInstitute of Translational Health SciencesChildren's National HospitalUniversity of Arkansas for Medical SciencesVanderbilt University Medical CenterTranslational Research Institute, University of Arkansas for Medical SciencesNorthShore University HealthSystemSouthern California Clinical and Translational Science InstituteUniversity at BuffaloUniversity of RochesterAurora Health CareUniversity of North Carolina at Chapel HillChildren’s Hospital of Wisconsin Research InstituteUniversity of MiamiUniversity of South CarolinaRutgers, The State University of New JerseyInstitute for Clinical and Translational Research, University of Wisconsin, MadisonPennsylvania State UniversityVanderbilt Institute for Clinical and Translational ResearchUniversity of CincinnatiInstitute of Clinical and Translational SciencesUniversity of Texas Medical BranchUniversity of California, San DiegoJohns Hopkins UniversityUniversity of California, Los AngelesBill and Melinda Gates FoundationUniversity of WashingtonFrontiers Clinical and Translational Science Institute, University of KansasLoyola University ChicagoUniversity of Texas Health Science Center at HoustonWashington University in St. LouisUniversity of MichiganUniversity of Southern CaliforniaHarvard CatalystUniversity of MinnesotaUniversity of PennsylvaniaGeorge Washington UniversityMichigan Institute for Clinical and Health ResearchUniversity of UtahChildren's Hospital ColoradoYork UniversityNorthwestern UniversityVanderbilt UniversityAccelerated Innovation Research Initiative Turning Top Science and Ideas into High-Impact ValuesUniversity of ChicagoGeorgia Clinical and Translational Science AllianceIrving Medical Center, Columbia UniversityVirginia Commonwealth UniversityTulane UniversityBrown UniversityRush UniversityCincinnati Children's Hospital Medical CenterUniversity of Wisconsin-MadisonPenn State Clinical and Translational Science InstituteOhio State UniversityCarilion Clinic
Mots-clésCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakCoding (social sciences)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)DiseaseInfectious disease (medical specialty)VirologyMedicineMathematicsStatisticsOutbreakInternal medicine

Résumé

récupéré en direct d'OpenAlex

Background: Naming a newly discovered disease is a difficult process; in the context of the COVID-19 pandemic and the existence of post-acute sequelae of SARS-CoV-2 infection (PASC), which includes Long COVID, it has proven especially challenging. Disease definitions and assignment of a diagnosis code are often asynchronous and iterative. The clinical definition and our understanding of the underlying mechanisms of Long COVID are still in flux, and the deployment of an ICD-10-CM code for Long COVID in the US took nearly two years after patients had begun to describe their condition. Here we leverage the largest publicly available HIPAA-limited dataset about patients with COVID-19 in the US to examine the heterogeneity of adoption and use of U09.9, the ICD-10-CM code for "Post COVID-19 condition, unspecified." Methods: = 21,072), including assessing person-level demographics and a number of area-level social determinants of health; diagnoses commonly co-occurring with U09.9, clustered using the Louvain algorithm; and quantifying medications and procedures recorded within 60 days of U09.9 diagnosis. We stratified all analyses by age group in order to discern differing patterns of care across the lifespan. Results: We established the diagnoses most commonly co-occurring with U09.9, and algorithmically clustered them into four major categories: cardiopulmonary, neurological, gastrointestinal, and comorbid conditions. Importantly, we discovered that the population of patients diagnosed with U09.9 is demographically skewed toward female, White, non-Hispanic individuals, as well as individuals living in areas with low poverty, high education, and high access to medical care. Our results also include a characterization of common procedures and medications associated with U09.9-coded patients. Conclusions: This work offers insight into potential subtypes and current practice patterns around Long COVID, and speaks to the existence of disparities in the diagnosis of patients with Long COVID. This latter finding in particular requires further research and urgent remediation.

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.

Comment cette classification a été obtenuedéplier

Prédiction distillée sur la base complète

Imitation des enseignants

Ni prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.

score de la tête « metaresearch » (Codex)0,001
score de la tête « metaresearch » (Gemma)0,002
Version: codex-gemma-dda1882f352aStatut de validation: machine_predicted_unvalidated
Catégories candidatesMéta-épidémiologie (sens strict), Charge utile insuffisante (le modèle a refusé de juger)
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Observationnel · Signal consensuel: Observationnel
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,219
Score d'incertitude au seuil0,999

Scores Codex et Gemma par catégorie

CatégorieCodexGemma
Métarecherche0,0010,002
Méta-épidémiologie (sens strict)0,0010,001
Méta-épidémiologie (sens large)0,0010,001
Bibliométrie0,0000,000
Études des sciences et des technologies0,0000,000
Communication savante0,0000,001
Science ouverte0,0010,002
Intégrité de la recherche0,0000,002
Charge utile insuffisante (le modèle a refusé de juger)0,0050,000

Scores machine (provisoires)

Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.

Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.

Tête enseignante Opus0,048
Tête enseignante GPT0,344
Écart entre enseignants0,296 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validationscore_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle

Classification

machine, non validée

Prédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.

Devis d'étudeObservationnel
Domainenon disponible
GenreEmpirique

Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».

En bref

Citations30
Publié2022
Routes d'admission1
Résumé présentoui

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