A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
2012· article· en· Nature· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
958
citations
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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
2015· article· en· Nature Medicine· Medicine
affsans résumé
711
citations
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
2012· article· en· Nature Medicine· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
654
citations
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
2012· article· en· Nature· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
614
citations
PLU-1 Is an H3K4 Demethylase Involved in Transcriptional Repression and Breast Cancer Cell Proliferation
2007· article· en· Molecular Cell· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
481
citations
Demethylase Activity Is Directed by Histone Acetylation
2001· article· en· Journal of Biological Chemistry· Biochemistry, Genetics and Molecular Biology
aff
293
citations
Cooperative Epigenetic Modulation by Cancer Amplicon Genes
2010· article· en· Cancer Cell· Medicine
afffundsans résumé
278
citations
Structural Basis of Human CYP51 Inhibition by Antifungal Azoles
2010· article· en· Journal of Molecular Biology· Pharmacology, Toxicology and Pharmaceutics
afffundsans résumé
266
citations
HISTONE DEACETYLASE6 Interacts with FLOWERING LOCUS D and Regulates Flowering in Arabidopsis
2011· article· en· PLANT PHYSIOLOGY· Agricultural and Biological Sciences
aff
261
citations
DNA Methylation and Histone Modifications Regulate De Novo Shoot Regeneration in Arabidopsis by Modulating WUSCHEL Expression and Auxin Signaling
2011· article· en· PLoS Genetics· Agricultural and Biological Sciences
fundno aff
245
citations
Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock
2011· article· en· Science· Neuroscience
aff
242
citations
Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium
2012· review· en· Metallomics· Biochemistry, Genetics and Molecular Biology
fundno aff
239
citations
Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis
2016· article· en· Nature Genetics· Agricultural and Biological Sciences
affsans résumé
239
citations
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy
2010· article· en· Nature Chemical Biology· Medicine
affsans résumé
237
citations
Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors
2010· article· en· PLoS ONE· Biochemistry, Genetics and Molecular Biology
fundno aff
224
citations
The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation
2017· article· en· Neuropsychopharmacology· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
213
citations
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing
2016· article· en· Cell Discovery· Medicine
fundno aff
204
citations
Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development
2011· article· en· PLoS ONE· Biochemistry, Genetics and Molecular Biology
afffund
200
citations
Crystal Structures of the Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition
2014· article· en· Journal of Biological Chemistry· Biochemistry, Genetics and Molecular Biology
aff
195
citations
Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N6-Methyladenosine RNA Demethylation
2014· article· en· Journal of Biological Chemistry· Biochemistry, Genetics and Molecular Biology
aff
187
citations
The Methyl Donor S-Adenosylmethionine Inhibits Active Demethylation of DNA
2003· article· en· Journal of Biological Chemistry· Biochemistry, Genetics and Molecular Biology
afffund
181
citations
Promoter-specific Activation and Demethylation by MBD2/Demethylase
2002· article· en· Journal of Biological Chemistry· Biochemistry, Genetics and Molecular Biology
aff
179
citations
Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family
2011· article· en· Journal of Biological Chemistry· Biochemistry, Genetics and Molecular Biology
fundno aff
176
citations
Histone deacetylases 1 and 2 are expressed at distinct stages of neuro‐glial development
2008· article· en· Developmental Dynamics· Biochemistry, Genetics and Molecular Biology
afffund
167
citations
Maternal Protein Restriction Elevates Cholesterol in Adult Rat Offspring Due to Repressive Changes in Histone Modifications at the Cholesterol 7α-Hydroxylase Promoter
2011· article· en· Molecular Endocrinology· Medicine
aff
166
citations