Targeting ataxia-telangiectasia mutated deficient malignancies with poly ADP ribose polymerase inhibitors
Bibliographic record
Abstract
Small molecule inhibitors of poly ADP ribose polymerase (PARP) have shown considerable promise as therapeutic agents in human malignancies with disruption of the breast and ovarian cancer susceptibility genes BRCA1 or BRCA2 . Evidence is also accumulating that disruption of other genes involved in the detection and/or repair of DNA damage, in particular DNA double strand breaks (DSBs), may also have a synthetic lethal relationship with PARP. One of these is the DNA damage activated protein kinase, ataxia-telangiectasia mutated (ATM). Several studies have shown that ATM deficiency is common in a broad range of hematological and solid malignancies. Here, we discuss the potential for using PARP inhibitors in human cancers with mutation or disruption of ATM .
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".